Back to top Autoimmune response In an autoimmune response, lymphocytes are unleashed against the body cells. The Journal of Clinical Investigation. Signalling from the APC directs T cells into particular subtypes. Immunology and Cell Biology.
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At least weeks exposure is needed to establish exhaustion. Biology of Blood and Marrow Transplantation. Ina team of researchers led by Dr.
Effector cells are the superset of all the various T cell types that actively respond immediately to a stimulus, such as co-stimulation. However, some of these cells are selected to become Treg cells. Haematopoietic progenitors lymphoid progenitor cells from haematopoietic stem cells populate the thymus and expand by cell division to generate a large population of immature thymocytes. Negative selection in the medulla then obliterates T cells that bind too strongly to self-antigens expressed on MHC molecules.